反应详情

10 g (0.023 mol) of 2,4,6-tribromophenylamine are dissolved in 100 ml of THF. In a second apparatus, 228 ml of phenylmagnesium bromide is heated under reflux. The dissolved 2,4,6-tribromophenylamine is added dropwise to the phenylmagnesium bromide solution, stirred under reflux for 1 h and at room temperature for a further 12 h. After addition of saturated sodium chloride solution, the aqueous phase is washed with diethyl ether and dried over sodium sulfate. After removal of the solvent, the product is recrystallised in hexane/dichloromethane. 4.8 g (77%) of clean substance are isolated.

1. temperatureunder reflux
2. washthe aqueous phase is washed with diethyl ether
3. dry with materialdried over sodium sulfate
4. customAfter removal of the solvent
5. customthe product is recrystallised in hexane/dichloromethane
6. custom4.8 g (77%) of clean substance are isolated