反应详情

To a suspension of methyl 2,3-diaminobenzoate (32.9 g, 198 mmol) in tetrahydrofuran (300 mL) was added N,N′-carbonyldiimidazole (33.7 g, 208 mmol), and the mixture was stirred at room temperature for 15 hr. The solvent was evaporated in vacuo, and the residual solid was suspended in ethyl acetate (110 mL) and stirred at 80° C. After 30 min, the mixture was stirred at room temperature for 1 hr, and the resulting solid was collected by filtration and washed with ethyl acetate to give the title compound (35.6 g, 185 mmol, 94%) as a colorless solid.

1. customThe solvent was evaporated in vacuo
2. stirringstirred at 80° C
3. waitAfter 30 min
4. stirringthe mixture was stirred at room temperature for 1 hr
5. filtrationthe resulting solid was collected by filtration
6. washwashed with ethyl acetate