Potassium Cation → 4-[({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]-1-(2-hydroxyethyl)piperidine-4-carboxamide

HRID 162860Notes

Reaction equation

HRID 162860 reaction equation
[Br:1][CH2:2][CH2:3][OH:4].[C:38](=[O:39])([O-:40])[O-:41].[Cl:5][c:6]1[c:7]([F:37])[c:8]([NH:12][c:13]2[n:14][cH:15][n:16][c:17]3[cH:18][c:19]([O:35][CH3:36])[c:20]([CH2:23][N:24]([C:25]4([C:31](=[O:32])[NH2:33])[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]4)[CH3:34])[cH:21][c:22]23)[cH:9][cH:10][cH:11]1.[K+:42].[K+:43].[S:44]1(=[O:45])(=[O:46])[CH2:47][CH2:48][CH2:49][CH2:50]1>>[CH2:2]([CH2:3][OH:4])[N:28]1[CH2:27][CH2:26][C:25]([N:24]([CH2:23][c:20]2[c:19]([O:35][CH3:36])[cH:18][c:17]3[n:16][cH:15][n:14][c:13]([NH:12][c:8]4[c:7]([F:37])[c:6]([Cl:5])[cH:11][cH:10][cH:9]4)[c:22]3[cH:21]2)[CH3:34])([C:31](=[O:32])[NH2:33])[CH2:30][CH2:29]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 108982-BromoethanolHCID 19660Carbonate IonHCID 31347SulfolaneHCID 57979867HCID 57979867, compound

Product 1

HCID 579798824-[({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]-1-(2-hydroxyethyl)piperidine-4-carboxamide

Sources & evidence

ORD record
ord-ffe32749417f4102836b998c666f36ab
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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