4-Methoxybenzylamine → HCID 68355400, compound

HRID 1629031Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][NH2:8])=[CH:5][CH:4]=1.[O-:11][C:12]#[N:13].[Na+]>>[CH:6]([C:5]1[NH:13][C:12](=[O:11])[N:8]([CH2:7][C:6]2[CH:9]=[CH:10][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH:4]=1)([CH3:9])[CH3:7]

Participants

Reactant 2

HCID 754524-Methoxybenzylamine

HCID 517096Sodium Cyanate

Product 1

HCID 68355400HCID 68355400, compound

Procedure

3-Methylbutan-2-one was brominated with bromine in methanol to give 1-bromo-3-methylbutan-2-one which was reacted with 4-methoxybenzylamine and cyclized with sodium cyanate to give 4-isopropyl-1-(4-methoxybenzyl)-1H-imidazol-2(3H)-one.

Sources & evidence

ORD record: ord-d493bc90d5984a1186c0c0fe8f1eb65c
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08785626B2

Reaction notes

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