反应详情

Following the procedures of Example 339, 2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a,9-triaza-benzo[e]azulen-8-ol from Example 93 and 4-hydroxypiperidine, the crude product was recrystallised from methanol to give 340 as a white solid (106 mg, 42%). LCMS: RT=2.48 min, [M+H]+=396. 1 H NMR 400 MHz (DMSO-d6) δ: 9.09 (1 H, s), 7.88 (1 H, d, J=0.64 Hz), 7.83 (1 H, s), 6.33 (1 H, s), 5.97-5.88 (1 H, m), 4.69 (1 H, d, J=4.26 Hz), 4.49-4.48 (4 H, m), 4.03-3.99 (2 H, m), 3.75-3.67 (1 H, m), 3.14-3.13 (2 H, m), 1.80-1.71 (2 H, m), 1.47 (6 H, d, J=6.60 Hz), 1.34-1.33 (2 H, m)

1. customthe crude product was recrystallised from methanol