HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl azetidine-3-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 1-Boc-Azetidine-3-carboxylic acid | HCID 2755981 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl azetidine-3-carboxylate hydrochloride | HCID 21100040 | — |
Reaction Steps
To a solution of 1-(tert-butoxycarbonyl)azetidine-3-carboxylic acid (8.00 g, 39.8 mmol) in MeOH (60 mL) was added 4 M HCl in dioxane (60 mL, 240.0 mmol). The mixture was refluxed for 2 hours. The mixture was concentrated to afford INT 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791100B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-2ca3c025209246cfa101a2cce959d64a |
| Source note | uspto-grants-2014_07 |