Hydrochloric Acid → Methyl azetidine-3-carboxylate hydrochloride

HRID 1629695Notes

Reaction equation

HRID 1629695 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12]([OH:14])=[O:13])[CH2:9]1)=O)(C)(C)C.[ClH:15].O1CCOC[CH2:17]1>CO>[ClH:15].[CH3:17][O:14][C:12]([CH:10]1[CH2:9][NH:8][CH2:11]1)=[O:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 27559811-Boc-Azetidine-3-carboxylic acid

Product 1

HCID 21100040Methyl azetidine-3-carboxylate hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1-(tert-butoxycarbonyl)azetidine-3-carboxylic acid (8.00 g, 39.8 mmol) in MeOH (60 mL) was added 4 M HCl in dioxane (60 mL, 240.0 mmol). The mixture was refluxed for 2 hours. The mixture was concentrated to afford INT 1.

Workup

  1. temperatureThe mixture was refluxed for 2 hours
  2. concentrationThe mixture was concentrated
  3. customto afford INT 1

Sources & evidence

ORD record
ord-2ca3c025209246cfa101a2cce959d64a
Source dataset
uspto-grants-2014_07
Patent number
US08791100B2

Reaction notes

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