HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 3-methylazetidine-3-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Tert-butyl 3-methyl 3-methylazetidine-1,3-dicarboxylate | HCID 57415890 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 3-methylazetidine-3-carboxylate hydrochloride | HCID 67329141 | — |
Reaction Steps
To a solution of INT 13 (1.66 g, 7.24 mmol) in CH2Cl2 was added HCl (2.0 M in Et2O, 36.2 mL, 72.4 mmol). The reaction mixture was stirred at room temperature for 20 hours. The mixture was concentrated to afford INT 14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791100B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-76244b54abf84904a71c0776b0fe435c |
| Source note | uspto-grants-2014_07 |