Hydrochloric Acid → Methyl 3-methylazetidine-3-carboxylate hydrochloride

HRID 1629710Notes

Reaction equation

HRID 1629710 reaction equation
[CH3:1][O:2][C:3]([C:5]1([CH3:16])[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)=[O:4].[ClH:17]>C(Cl)Cl>[ClH:17].[CH3:1][O:2][C:3]([C:5]1([CH3:16])[CH2:8][NH:7][CH2:6]1)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 574158901-Tert-butyl 3-methyl 3-methylazetidine-1,3-dicarboxylate

Product 1

HCID 67329141Methyl 3-methylazetidine-3-carboxylate hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of INT 13 (1.66 g, 7.24 mmol) in CH2Cl2 was added HCl (2.0 M in Et2O, 36.2 mL, 72.4 mmol). The reaction mixture was stirred at room temperature for 20 hours. The mixture was concentrated to afford INT 14.

Workup

  1. concentrationThe mixture was concentrated
  2. customto afford INT 14

Sources & evidence

ORD record
ord-76244b54abf84904a71c0776b0fe435c
Source dataset
uspto-grants-2014_07
Patent number
US08791100B2

Reaction notes

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