HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 1-{2-Chloro-5-[(S)-1-(4-chloro-3-methyl-phenyl)-2,2,2-trifluoro-ethylamino]-benzyl}-3-methyl-azetidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (S)-1-(4-chloro-3-methyl-phenyl)-2,2,2-trifluoro-ethylamine hydrochloride | HCID 57517340 | — |
| Reactant | Methyl 3-methylazetidine-3-carboxylate hydrochloride | HCID 67329141 | — |
| Product | 1-{2-Chloro-5-[(S)-1-(4-chloro-3-methyl-phenyl)-2,2,2-trifluoro-ethylamino]-benzyl}-3-methyl-azetidine-3-carboxylic acid | HCID 53339656 | — |
Reaction Steps
The title compound was prepared according to Scheme 4 following a procedure analogous to Example 61 using 3-methyl-azetidine-3-carboxylic acid methyl ester hydrochloride (INT 14) in step 1 and (S)-1-(4-chloro-3-methyl-phenyl)-2,2,2-trifluoro-ethylamine hydrochloride in step 2, followed by a LiOH-mediated ester cleavage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791100B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-8c83f63bb9b54a9f8fa05ac593c23d00 |
| Source note | uspto-grants-2014_07 |