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HRID1629753

反应详情

EQUATION

反应方程式

HRID 1629753 的结构方程式

REACTANTS

反应物

3
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：Cc1cc([C@H](N)C(F)(F)F)ccc1Cl.Cl
HCID57517340

未命名化合物

结构：COC(=O)C1(C)CNC1.Cl
HCID67329141

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc([C@H](Nc2ccc(Cl)c(CN3CC(C)(C(=O)O)C3)c2)C(F)(F)F)ccc1Cl
HCID53339656

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to Scheme 4 following a procedure analogous to Example 61 using 3-methyl-azetidine-3-carboxylic acid methyl ester hydrochloride (INT 14) in step 1 and (S)-1-(4-chloro-3-methyl-phenyl)-2,2,2-trifluoro-ethylamine hydrochloride in step 2, followed by a LiOH-mediated ester cleavage.