Diisopropylethylamine → Methyl 4-(6-bromo-hexanoyl-amino)-3-methyl-benzoate

HRID 1629811Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1629811
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](Cl)=[O:8].[NH2:10][C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][C:12]=1[CH3:21].CCN(C(C)C)C(C)C>C1COCC1>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([NH:10][C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][C:12]=1[CH3:21])=[O:8]

Komponenten

5

Edukt 3

HCID 81531DiisopropylethylamineHCID 898486-Bromohexanoyl chlorideHCID 2736799Methyl 4-amino-3-methylbenzoate

Produkt 1

HCID 69206251Methyl 4-(6-bromo-hexanoyl-amino)-3-methyl-benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A solution of 2.14 g (10 mmol) 6-bromo-hexanoylchloride in 5.0 ml THF is slowly added dropwise with stirring at ambient temperature to 1.65 g (10 mmol) methyl 4-amino-3-methyl-benzoate in 50 ml THF with 2 ml DIPEA. After 16 hours stirring at ambient temperature the mixture is evaporated down i. vac., the residue is dissolved in dichloromethane, washed twice with water and dried over sodium sulphate. The residue remaining after evaporation i. vac. is further reacted without any more purification.

Aufarbeitung

  1. customis evaporated down i
  2. dissolution, the residue is dissolved in dichloromethane
  3. washwashed twice with water
  4. dry with materialdried over sodium sulphate
  5. customafter evaporation i
  6. customis further reacted without any more purification

Quellen und Nachweise

ORD-Eintrag
ord-34a7d11b1bcb4aeb8894cc36da4d697c
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08791103B2

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