反应详情

A solution of 2.14 g (10 mmol) 6-bromo-hexanoylchloride in 5.0 ml THF is slowly added dropwise with stirring at ambient temperature to 1.65 g (10 mmol) methyl 4-amino-3-methyl-benzoate in 50 ml THF with 2 ml DIPEA. After 16 hours stirring at ambient temperature the mixture is evaporated down i. vac., the residue is dissolved in dichloromethane, washed twice with water and dried over sodium sulphate. The residue remaining after evaporation i. vac. is further reacted without any more purification.

1. customis evaporated down i
2. dissolution, the residue is dissolved in dichloromethane
3. washwashed twice with water
4. dry with materialdried over sodium sulphate
5. customafter evaporation i
6. customis further reacted without any more purification