Ammonia → 4-Fluoro-3-methylbenzamide

HRID 1629816Notes

Reaction equation

HRID 1629816 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[CH3:11].[NH3:12]>C1COCC1>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:12])=[O:7])=[CH:4][C:3]=1[CH3:11]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27745894-Fluoro-3-methylbenzoyl chloride

Product 1

HCID 27745784-Fluoro-3-methylbenzamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

15.70 g (91.0 mmol) 4-fluoro-3-methyl-benzoic acid chloride dissolved in 30 ml THF are added dropwise to 300 ml of conc. ammonia solution and then stirred for 2 hours at ambient temperature. The precipitate formed is filtered off, washed with water and dried.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-a1aa46db4ffb4027ae51c5fab878a6bb
Source dataset
uspto-grants-2014_07
Patent number
US08791103B2

Reaction notes

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