Lithium Hydroxide → HCID 67048642, compound

HRID 1629825Notes

Reaction equation

HRID 1629825 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N:12]1[CH2:18][CH2:17][CH2:16][CH2:15][O:14][C:13]1=[O:19])[C:5]([O:7]C)=[O:6].[OH-].[Li+]>C(O)C>[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N:12]1[CH2:18][CH2:17][CH2:16][CH2:15][O:14][C:13]1=[O:19])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67048344HCID 67048344, compound

Product 1

HCID 67048642HCID 67048642, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

150 mg (0.57 mmol) methyl 3-methyl-4-([1,3]oxazepan-2-on-3-yl)-benzoate are suspended in 1 ml of ethanol and combined with 0.26 ml (0.87 mmol) 8% aqueous lithium hydroxide solution. The mixture is stirred for 3 hours at ambient temperature and then evaporated down i. vac. The aqueous residue is extracted twice with ethyl acetate, then acidified and extracted twice more with ethyl acetate. The combined organic phases are dried over sodium sulphate and evaporated down i. vac.

Workup

  1. customevaporated down i
  2. extractionThe aqueous residue is extracted twice with ethyl acetate
  3. extractionextracted twice more with ethyl acetate
  4. dry with materialThe combined organic phases are dried over sodium sulphate
  5. customevaporated down i

Sources & evidence

ORD record
ord-1e6a6fccff204e6a940ea8c8b50d33d0
Source dataset
uspto-grants-2014_07
Patent number
US08791103B2

Reaction notes

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