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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1629893Generated: October 30, 2026

Tetrahydrofuran → Ethyl 4-[(2-chloro-ethoxy)-acetyl-amino]-3-fluoro-benzoate

https://huagongshe.com/reaction/1629893

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
Reactant2-(2-Chloroethoxy)acetyl chlorideHCID 19048420—
ReactantEthyl 4-Amino-3-fluorobenzoateHCID 20536493—
ProductEthyl 4-[(2-chloro-ethoxy)-acetyl-amino]-3-fluoro-benzoateHCID 86600579—

Reaction Steps

Prepared analogously to Example 46a from (2-chloro-ethoxy)-acetylchloride and ethyl 4-amino-3-fluoro-benzoate with TEA in THF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08791103B2
Source datasetuspto-grants-2014_07
ORD IDord-12acf473561f451b894bfb4c54a7a532
Source noteuspto-grants-2014_07