Tetrahydrofuran → Ethyl 4-[(2-chloro-ethoxy)-acetyl-amino]-3-fluoro-benzoate

HRID 1629893Notes

Reaction equation

HRID 1629893 reaction equation
[Cl:1][CH2:2][CH2:3][O:4]CC(Cl)=O.[NH2:9][C:10]1[CH:20]=[CH:19][C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:12][C:11]=1[F:21].C1C[O:25][CH2:24][CH2:23]1>>[Cl:1][CH2:2][CH2:3][O:4][N:9]([C:24](=[O:25])[CH3:23])[C:10]1[CH:20]=[CH:19][C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:12][C:11]=1[F:21]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 190484202-(2-Chloroethoxy)acetyl chlorideHCID 20536493Ethyl 4-amino-3-fluorobenzoate

Product 1

HCID 86600579Ethyl 4-[(2-chloro-ethoxy)-acetyl-amino]-3-fluoro-benzoate

Procedure

Prepared analogously to Example 46a from (2-chloro-ethoxy)-acetylchloride and ethyl 4-amino-3-fluoro-benzoate with TEA in THF.

Sources & evidence

ORD record
ord-12acf473561f451b894bfb4c54a7a532
Source dataset
uspto-grants-2014_07
Patent number
US08791103B2

Reaction notes

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