HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- → (S)-2-amino-3-(benzyloxy)-N-(3-chloro-4-phenoxyphenyl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- | HCID 90234 | — |
| Reactant | 3-Chloro-4-phenoxyaniline | HCID 220320 | — |
| Product | (S)-2-amino-3-(benzyloxy)-N-(3-chloro-4-phenoxyphenyl)propanamide | HCID 67009397 | 70% |
Reaction Steps
Proceeding as in Reference 5, but substituting 3-chloro-4-phenoxyaniline and (S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoic acid, gave (S)-2-amino-3-(benzyloxy)-N-(3-chloro-4-phenoxyphenyl)propanamide (470 mg, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791102B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-bbbe02019c3940d7b8af0150b86b978d |
| Source note | uspto-grants-2014_07 |