Acetate-hydrochloric acid → (S)-2-acetamido-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide

Participants

Reaction Steps

Proceeding as in Example 1, but substituting acetic acid hydrochloride and (S)-2-amino-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 164, (S)-2-acetamido-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (35 mg, 60%). 1H-NMR (400 MHz, CDCl3): δ 8.40 (s, 1H), 7.40-7.25 (m, 5H), 7.10-6.90 (m, 7H), 6.45-6.40 (m, 1H), 4.80-4.45 (m, 3H), 4.00-3.90 (m, 1H), 3.60 (m, 1H), 1.60 (s, 3H). MS (EI) for C24H22F2N2O4 found 441 (MH+).

Provenance & Evidence