反应详情

温度

80 °C

A flask was charged with (2S,4S)-4-((5-chlorothien-2-yl)methyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (340 mg, 0.861 mmol), prepared as in Reference 6, palladium on carbon (10%, 50 mg), ammonium formate (200 mg, 3.33 mmol) and methanol (10 mL) and the mixture was heated to 80° C. The mixture was stirred at 80° C. for 30 minutes, filtered and then concentrated to give crude (2S,4S)—N-(4-(4-fluorophenoxy)phenyl)-4-(thien-2-ylmethyl)pyrrolidine-2-carboxamide (0.252 mg, 0.636 mmol), which was carried forward without further purification.

1. filtrationfiltered
2. concentrationconcentrated