Hydrazine hydrate (1:1) → HCID 23016677, compound

HRID 1630360Notes

Reaction equation

HRID 1630360 reaction equation
O.[NH2:2][NH2:3].Cl[C:5]1[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][N:8]=[C:7]([S:16][CH3:17])[N:6]=1>C(O)C>[NH:2]([C:5]1[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][N:8]=[C:7]([S:16][CH3:17])[N:6]=1)[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 800084-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester

Product 1

HCID 23016677HCID 23016677, compoundYield 65.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
0 °C

Procedure

9.71 g of hydrazine monohydrate was dissolved in 200 mL of ethanol, and cooled to 0° C. To this was added a solution prepared by dissolving 15.0 g of ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate in 200 mL of ethanol, and stirred for 1 hour. The precipitated solid was taken out through filtration, washed with distilled water, and dried to obtain 9.66 g of the entitled compound as a white solid.

Workup

  1. additionTo this was added a solution
  2. customprepared
  3. filtrationThe precipitated solid was taken out through filtration
  4. washwashed with distilled water
  5. customdried

Sources & evidence

ORD record
ord-a333f505cdae4b4e9e535328b91df412
Source dataset
uspto-grants-2014_07
Patent number
US08791125B2

Reaction notes

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