Water → HCID 63961722, compound

HRID 1630386Notes

Reaction equation

HRID 1630386 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[OH2:9]>>[Br:8][C:4]1[N:3]=[C:2]([N:3]([CH3:4])[CH2:2][CH2:7][OH:9])[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 962WaterHCID 122742,6-Dibromopyridine

Product 1

HCID 63961722HCID 63961722, compound

Procedure

7.45 g of 2,6-dibromopyridine and 12 mL of N-methylethanol were stirred overnight at 140° C. Water was added to the reaction liquid, extracted with ethyl acetate, washed with saturated saline water, and dried with anhydrous magnesium sulfate. After concentrated under reduced pressure, the residue was purified through silica gel column chromatography (hexane/ethyl acetate=1/1) to obtain 3.98 g of the entitled compound as a colorless oily substance.

Workup

  1. extractionextracted with ethyl acetate
  2. washwashed with saturated saline water
  3. dry with materialdried with anhydrous magnesium sulfate
  4. concentrationAfter concentrated under reduced pressure
  5. customthe residue was purified through silica gel column chromatography (hexane/ethyl acetate=1/1)

Sources & evidence

ORD record
ord-ac28e240ead8464fa7ff617e08722291
Source dataset
uspto-grants-2014_07
Patent number
US08791125B2

Reaction notes

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