HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-Nitro-1H-pyrazole 3-cyclopropylmethylcarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (Cyclopropylmethyl)ammonium chloride | HCID 81671 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 5-Nitro-1H-pyrazole-3-carboxylic acid | HCID 86222684 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Nitro-1H-pyrazole 3-cyclopropylmethylcarboxamide | HCID 131731699 | — |
Reaction Steps
7.5 g of 5-nitro-1H-pyrazole-3-carboxylic acid were dissolved in 70 ml of DMF. 19.9 g of HATU and 9.6 g of triethylamine are added at RT and, after stirring for 10 minutes, 5.1 g of aminomethylcyclopropane hydrochloride are added, and the mixture is stirred at RT overnight. After aqueous workup, the crude product is purified by column chromatography (silica gel, methanol:DCM=1:30).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791133B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-14de56f77c564579bc2accc5f05d4b58 |
| Source note | uspto-grants-2014_07 |