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HRID1630408

反应详情

EQUATION

反应方程式

HRID 1630408 的结构方程式

REACTANTS

反应物

4
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：Cl.NCC1CC1
HCID81671

(Cyclopropylmethyl)ammonium chloride

C4H10ClN

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：O=C(O)c1cc([N+](=O)[O-])[nH]n1
HCID86222684

5-Nitro-3-pyrazolecarboxylic acid

C4H3N3O4

PRODUCTS

生成物

1
结构：NC(=O)CC1CC1.O=[N+]([O-])c1ccn[nH]1
HCID131731699

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

7.5 g of 5-nitro-1H-pyrazole-3-carboxylic acid were dissolved in 70 ml of DMF. 19.9 g of HATU and 9.6 g of triethylamine are added at RT and, after stirring for 10 minutes, 5.1 g of aminomethylcyclopropane hydrochloride are added, and the mixture is stirred at RT overnight. After aqueous workup, the crude product is purified by column chromatography (silica gel, methanol:DCM=1:30).

WORKUP

后处理

  1. stirringthe mixture is stirred at RT overnight
  2. customAfter aqueous workup, the crude product is purified by column chromatography (silica gel, methanol:DCM=1:30)