反应详情

1 g of 5-nitro-1H-pyrazole-3-cyclopropylmethylcarboxamide is dissolved in 30 ml of methanol and 2 ml of acetic acid. This mixture is hydrogenated in the presence of 110 mg of Pd/C under 5 bar until reaction is complete. The mixture is filtered through celite, evaporated to dryness and purified by column chromatography (silica gel, methanol:DCM=1:30).

1. filtrationThe mixture is filtered through celite
2. customevaporated to dryness
3. custompurified by column chromatography (silica gel, methanol:DCM=1:30)