HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Nitro-1H-pyrazole 3-cyclopropylmethylcarboxamide → 5-Amino-1H-pyrazole 3-cyclopropylmethylcarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Nitro-1H-pyrazole 3-cyclopropylmethylcarboxamide | HCID 131731699 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Amino-1H-pyrazole 3-cyclopropylmethylcarboxamide | HCID 131731700 | — |
Reaction Steps
1 g of 5-nitro-1H-pyrazole-3-cyclopropylmethylcarboxamide is dissolved in 30 ml of methanol and 2 ml of acetic acid. This mixture is hydrogenated in the presence of 110 mg of Pd/C under 5 bar until reaction is complete. The mixture is filtered through celite, evaporated to dryness and purified by column chromatography (silica gel, methanol:DCM=1:30).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791133B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-c5d1c77c88d94e958324487cf1c64d4f |
| Source note | uspto-grants-2014_07 |