1,3-Cyclohexanedione, 4,4-dimethyl- → 4-{(E)-2-[5-(3-Fluorophenyl)pyridin-2-yl]vinyl}-6,6-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline 3-cyclopropylmethylcarboxamide

HRID 1630411Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1630411
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]=O)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:18][C:19]1([CH3:27])[CH2:24][CH2:23][C:22](=O)[CH2:21][C:20]1=[O:26].[NH2:28][C:29]1[NH:33][N:32]=[CH:31][CH:30]=1.[CH2:34]1[CH:36]([CH2:37][C:38]([NH2:40])=[O:39])[CH2:35]1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]3[C:21]4[C:20](=[O:26])[C:19]([CH3:27])([CH3:18])[CH2:24][CH2:23][C:22]=4[NH:28][C:29]4[NH:33][N:32]=[CH:31][C:30]3=4)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:35]1[CH:36]([CH2:37][C:38]([NH2:40])=[O:39])[CH2:34]1

Komponenten

4

Edukt 3

HCID 1363601,3-Cyclohexanedione, 4,4-dimethyl-HCID 86676729(E)-3-[5-(3-Fluorophenyl)pyridin-2-yl]propenalHCID 1317317005-Amino-1H-pyrazole 3-cyclopropylmethylcarboxamide

Produkt 1

HCID 1371957944-{(E)-2-[5-(3-Fluorophenyl)pyridin-2-yl]vinyl}-6,6-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline 3-cyclopropylmethylcarboxamide

Versuchsvorschrift

The title compound is prepared according to procedure A from 50 mg of (E)-3-[5-(3-fluorophenyl)pyridin-2-yl]propenal, 31 mg of 4,4-dimethylcyclohexane-1,3-dione and 40 mg of 5-amino-1H-pyrazole-3-cyclopropylmethylcarboxamide.

Quellen und Nachweise

ORD-Eintrag
ord-d2e7f199afee4d3d832462eb0324b93b
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08791133B2

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