Trifluoroacetic acid → HCID 178426732, compound

HRID 1630416Notes

Reaction equation

HRID 1630416 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]3[C:25]4[C:24](=[O:26])[CH2:23][C:22]([CH3:28])([CH3:27])[CH2:21][C:20]=4[NH:19][C:18]4[NH:29][N:30]=[C:31]([C:32]([O:34]C(C)(C)C)=[O:33])[C:17]3=4)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]3[C:25]4[C:24](=[O:26])[CH2:23][C:22]([CH3:27])([CH3:28])[CH2:21][C:20]=4[NH:19][C:18]4[NH:29][N:30]=[C:31]([C:32]([OH:34])=[O:33])[C:17]3=4)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178426733HCID 178426733, compound

Product 1

HCID 178426732HCID 178426732, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

83 mg of tert-butyl 4-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]vinyl}-7,7-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline-3-carboxylate are dissolved in DCM (2.5 ml), admixed with TFA (2.5 ml) and stirred at RT for 3 h. The solvent is removed under reduced pressure, and the residue is suspended in toluene and concentrated by rotary evaporation once again. The resulting solid is used further without purification.

Workup

  1. customThe solvent is removed under reduced pressure
  2. concentrationconcentrated by rotary evaporation once again
  3. customThe resulting solid is used further without purification

Sources & evidence

ORD record
ord-d70e3318d6c242c88ea13d3134cf2868
Source dataset
uspto-grants-2014_07
Patent number
US08791133B2

Reaction notes

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