Trifluoroacetic acid → HCID 178449529, compound

HRID 1630418Notes

Reaction equation

HRID 1630418 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]3[C:25]4[C:24](=[O:26])[CH2:23][C:22]([CH3:28])([CH3:27])[CH2:21][C:20]=4[NH:19][C:18]4[NH:29][N:30]=[C:31]([C:32]([O:34][CH2:35][C:36]([CH3:47])([CH3:46])[CH2:37][NH:38]C(OC(C)(C)C)=O)=[O:33])[C:17]3=4)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.[C:48]([OH:54])([C:50]([F:53])([F:52])[F:51])=[O:49]>C(Cl)Cl>[F:51][C:50]([F:53])([F:52])[C:48]([OH:54])=[O:49].[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]3[C:25]4[C:24](=[O:26])[CH2:23][C:22]([CH3:28])([CH3:27])[CH2:21][C:20]=4[NH:19][C:18]4[NH:29][N:30]=[C:31]([C:32]([O:34][CH2:35][C:36]([CH3:47])([CH3:46])[CH2:37][NH2:38])=[O:33])[C:17]3=4)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178449795HCID 178449795, compound

Product 1

HCID 178449529HCID 178449529, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

40 mg of 3-tert-butoxycarbonylamino-2,2-dimethylpropyl 4-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]vinyl}-7,7-dimethyl-5-oxo-4,5,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinoline-3-carboxylate are dissolved in DCM (2.5 ml), admixed with TFA (2.5 ml) and stirred at RT for 3 h. The solvent is removed under reduced pressure, and the residue is suspended in toluene and concentrated by rotary evaporation once again. Yield: 63 mg; LC/MS (method J): m/z=543 (M+1); Rt=0.680 min

Workup

  1. customThe solvent is removed under reduced pressure
  2. concentrationconcentrated by rotary evaporation once again

Sources & evidence

ORD record
ord-188f415f055d4238ab74f72d6dd284c6
Source dataset
uspto-grants-2014_07
Patent number
US08791133B2

Reaction notes

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