Hydroxylamine → 1-(4-(Hydroxyimino)piperidin-1-yl)ethanone

HRID 1630422Notes

Reaction equation

[C:1]([N:4]1[CH2:9][CH2:8][C:7](=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[NH2:11][OH:12]>>[C:1]([N:4]1[CH2:9][CH2:8][C:7](=[N:11][OH:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 787Hydroxylamine

HCID 122563N-Acetyl-4-piperidone

Product 1

HCID 157079881-(4-(Hydroxyimino)piperidin-1-yl)ethanone

Procedure

1-Acetyl-piperidin-4-one oxime was prepared from 1-acetyl-piperidin-4-one and hydroxylamine using conditions of General Method 1. 1H NMR (400 MHz, DMSO-d6) δ 10.48 (1H, d, 3.2 Hz), 3.43-3.56 (4H, m), 2.48-2.56 (1H, m), 2.42 (1H, t, 6.2 Hz), 2.29-2.34 (1H, m), 2.17-2.26 (1H, m), 2.03 (3H, d, 4.2 Hz).

Sources & evidence

ORD record: ord-472a669a78d74a7fb250ec60b6279a98
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08791134B2

Reaction notes

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