N-Benzoyl-4-piperidone → 1-Benzoyl-piperidin-4-one oxime

HRID 1630423Notes

Reaction equation

HRID 1630423 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:17][OH:18]>>[C:1]([N:9]1[CH2:14][CH2:13][C:12](=[N:17][OH:18])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 90583N-Benzoyl-4-piperidoneHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 247008651-Benzoyl-piperidin-4-one oxime

Procedure

1-Benzoyl-piperidin-4-one oxime was prepared from 1-benzoyl-piperidin-4-one and hydroxylamine hydrochloride using conditions of General Method 1. 1H NMR (400 MHz, DMSO-d6) δ 10.53 (1H, br. s.), 7.29-7.54 (5H, m), 3.49-3.81 (4H, m), 2.44-2.66 (2H, m), 2.17-2.42(2H, m).

Sources & evidence

ORD record
ord-906b42d32b89497aaf680d90c6e00f25
Source dataset
uspto-grants-2014_07
Patent number
US08791134B2

Reaction notes

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