Hydrochloric Acid → HCID 86661391, compound

HRID 1630670Notes

Reaction equation

HRID 1630670 reaction equation
[Cl:1][C:2]1[C:3]([N:8]2[C:12]([C:13]([O:15]C)=[O:14])=[CH:11][C:10]([C:17]3[CH2:21][C:20]([C:26]4[CH:31]=[C:30]([Cl:32])[CH:29]=[C:28]([Cl:33])[CH:27]=4)([C:22]([F:25])([F:24])[F:23])[O:19][N:18]=3)=[N:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[OH-].[Na+].Cl>O.C(O)C>[Cl:1][C:2]1[C:3]([N:8]2[C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]([C:17]3[CH2:21][C:20]([C:26]4[CH:27]=[C:28]([Cl:33])[CH:29]=[C:30]([Cl:32])[CH:31]=4)([C:22]([F:25])([F:23])[F:24])[O:19][N:18]=3)=[N:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86661392HCID 86661392, compound

Product 1

HCID 86661391HCID 86661391, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

0.9 g of methyl 1-(3-chloropyridin-2-yl)-3-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-1H-pyrazole-5-carboxylate were dissolved in a mixture of 10 ml of water and 20 ml of ethanol, 0.2 g of sodium hydroxide were added and the mixture was stirred at RT for 3 h. The reaction was acidified with 2N hydrochloric acid, extracted three times with methyl tert-butyl ether and dried over magnesium sulphate. The product was obtained after distillative removal of the solvent.

Workup

  1. additionwere added
  2. extractionextracted three times with methyl tert-butyl ether
  3. dry with materialdried over magnesium sulphate
  4. customThe product was obtained
  5. customafter distillative removal of the solvent

Sources & evidence

ORD record
ord-98fccae81dc04e2bb7837439e21f62a3
Source dataset
uspto-grants-2014_07
Patent number
US08791139B2

Reaction notes

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