反应详情

Using Method X (but with no addition of K2CO3) with 2-(3,4,5-trimethoxyphenylamino)-6-chloropyrazine (150 mg) and phenol, the title compound was obtained (127 mg). Yield: 71%. 1H NMR (250 MHz, DMSO-d6) δ 3.31 (s, 9H), 3.54 (s, 3H), 6.77 (s, 2H), 7.16-7.23 (m, 3H), 7.41 (t, 2H, J=7.9 Hz), 7.75 (s, 1H), 7.95 (s, 1H), 9.53 (s, 1H). 13C NMR (62.9 MHz, DMSO-d6) δ 55.33, 60.03, 95.77, 120.55, 121.17, 124.47, 128.42, 129.74, 132.15, 136.29, 150.52, 152.69, 153.86, 153.86, 157.23. m/z 354.1 [(M+H)+ calcd for C19H19N3O4 353.1].