Oxalyl chloride → HCID 14222148, compound

HRID 1630814Notes

Reaction equation

HRID 1630814 reaction equation
O[CH2:2][NH:3][C:4](=[O:9])[C:5]([CH3:8])([CH3:7])[CH3:6].C(Cl)(=O)C([Cl:13])=O>ClCCl>[Cl:13][CH2:2][NH:3][C:4](=[O:9])[C:5]([CH3:8])([CH3:7])[CH3:6]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 13595971HCID 13595971, compound

Product 1

HCID 14222148HCID 14222148, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A flask is charged with N-hydroxymethyl-2,2-dimethyl-propionamide (0.500 g, 3.81 mmol) and dichloromethane (4 mL). Oxalyl chloride (0.8 mL, 9.52 mmol) is added and the reaction mixture is stirred at room temperature for 2 h. Concentration in vacuo gives N-chloromethyl-2,2-dimethyl-propionamide as a white solid. 1H NMR (400 MHz, CDCl3) δ ppm 1.23 (s, 9H), 5.31 (s, 2H).

Workup

  1. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-7631eeffebd4407fb99e4961287b82cb
Source dataset
uspto-grants-2014_07
Patent number
US08791141B2

Reaction notes

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