HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-N-hydroxy-nicotinamidine → 2-Chloro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-N-hydroxy-nicotinamidine | HCID 33678499 | — |
| Reactant | Methyl 4-bromo-3-(methoxymethyl)benzoate | HCID 58554220 | — |
| Product | 2-Chloro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}pyridine | HCID 46909302 | — |
Reaction Steps
The title compound was prepared following procedure described in Method B starting from Intermediate A1 and 6-chloro-N′-hydroxypyridine-3-carboximidamide (J. Med. Chem., 2005, 5215-5223). After purification by flash chromatography (silica, EtOAc/cHex), the title compound was obtained as a colorless oil (661 mg, 70%). HPLC (Method A), Rt: 5.8 min (purity: 99%). UPLC/MS, M+(ESI): 392.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791142B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-c1e2a3077e4d4a208d037e8d5a039b4b |
| Source note | uspto-grants-2014_07 |