反应详情

温度

130 °C

100 mg of (2-amino-6-iodoquinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone are dissolved in 2 ml of ethylene glycol dimethyl ether. 48 mg of 2-hydroxymethylphenylboronic acid, 66 mg of potassium carbonate, 14 mg of [1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloride and 50 μl of water are added to this solution, and the mixture is heated at 130° C. under argon for 30 min. The hot mixture is filtered off through Celite, and the solution is evaporated to dryness under reduced pressure. The reddish residue obtained is triturated with acetonitrile, during which a beige solid precipitates out. This is filtered, washed with acetonitrile and dried overnight at 40° C. in a drying cabinet.

1. filtrationThe hot mixture is filtered off through Celite
2. customthe solution is evaporated to dryness under reduced pressure
3. customThe reddish residue obtained
4. customis triturated with acetonitrile, during which a beige solid
5. customprecipitates out
6. filtrationThis is filtered
7. washwashed with acetonitrile
8. customdried overnight at 40° C. in a drying cabinet