反应详情

温度

120 °C

72 mg of 2-bromo-5-hydroxybenzaldehyde, 100 mg of potassium carbonate, 1 ml of water and 15 mg of [1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloride are added to a solution of 150 mg of [2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone in 3 ml of ethanol under argon. The mixture is heated at 120° C. for min; the hot mixture is filtered through kieselguhr, and the filtrate is evaporated. The residue obtained was triturated with 2 ml of acetonitrile, and the precipitate formed was filtered off with suction. Yield: 56 mg (38%) of 2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-5-hydroxybenzaldehyde; HPLC retention time: 1.67 min.

1. filtrationthe hot mixture is filtered through kieselguhr
2. customthe filtrate is evaporated
3. customThe residue obtained
4. customwas triturated with 2 ml of acetonitrile
5. customthe precipitate formed
6. filtrationwas filtered off with suction