反应详情

温度

120 °C

43 mg of (2-bromo-4,5-difluorophenyl)methanol, 80 mg of potassium carbonate, 4 μl of water and 16 mg of [1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloride are added to a solution of 100 mg of [2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone in 10 ml of ethanol under argon. The mixture is heated at 120° C. for 30 min; during which a precipitate forms. After cooling to 22° C., 10 ml of water are added, and the precipitate is filtered off. The residue is washed 3 times with 25 ml of ethanol each time and dried at 40° C. in vacuo.

1. temperatureAfter cooling to 22° C.
2. filtrationthe precipitate is filtered off
3. washThe residue is washed 3 times with 25 ml of ethanol each time
4. customdried at 40° C. in vacuo