反应详情

温度

120 °C

48 mg of (2-bromo-4,5-dimethoxyphenyl)methanol, 80 mg of potassium carbonate, 7 μl of water and 8 mg of [1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloride are added to a solution of 100 mg of [2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone in 10 ml of ethanol under argon. The mixture is heated at 120° C. for 30 min. The solid is filtered off through kieselguhr with suction, and the filtrate is evaporated to dryness in vacuo. The residue is dissolved in 1 ml of DMSO and chromatographed by means of prep. HPLC (Agilent). The product fractions obtained are subsequently evaporated and freeze-dried.

1. filtrationThe solid is filtered off through kieselguhr with suction
2. customthe filtrate is evaporated to dryness in vacuo
3. dissolutionThe residue is dissolved in 1 ml of DMSO
4. customchromatographed by means of prep
5. customThe product fractions obtained
6. customare subsequently evaporated
7. customfreeze-dried