Sodium Hydroxide → HCID 56943245, compound

Participants

Reaction Conditions

Reaction Steps

280 mg of methyl 1-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzyl}pyrrolidine-2-carboxylate are dissolved in 5 ml of tetrahydrofuran. 5 ml of 2N sodium hydroxide solution are added, and the mixture is stirred at 25° C. for 16 h. The mixture is evaporated in vacuo and acidified using 2N hydrochloric acid, during which the product precipitates out. Filtration and drying at 40° C. in vacuo gives 1-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzyl}pyrrolidine-2-carboxylic acid.

Provenance & Evidence