HRID1631138

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)C1CCCN1Cc1ccccc1-c1ccc2nc(N)nc(C(=O)N3Cc4ccccc4C3)c2c1

HCID56943244

未命名化合物

PRODUCTS

生成物

结构：Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(-c3ccccc3CN3CCCC3C(=O)O)ccc2n1

HCID56943245

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度: 25 °C

PROCEDURE

实验过程

280 mg of methyl 1-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzyl}pyrrolidine-2-carboxylate are dissolved in 5 ml of tetrahydrofuran. 5 ml of 2N sodium hydroxide solution are added, and the mixture is stirred at 25° C. for 16 h. The mixture is evaporated in vacuo and acidified using 2N hydrochloric acid, during which the product precipitates out. Filtration and drying at 40° C. in vacuo gives 1-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzyl}pyrrolidine-2-carboxylic acid.

WORKUP

后处理

customThe mixture is evaporated in vacuo
customduring which the product precipitates out
filtrationFiltration
customdrying at 40° C. in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fa00775251a843bf8709466dc6612722
来源数据集: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08791129B2
来源说明: uspto-grants-2014_07

反应 SMILES

[NH2:1][C:2]1[N:11]=[C:10]([C:12]([N:14]2[CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15]2)=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:23]3[CH:38]=[CH:37][CH:36]=[CH:35][C:24]=3[CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][CH:27]3[C:31]([O:33]C)=[O:32])[CH:8]=2)[N:3]=1.[OH-].[Na+]>O1CCCC1>[NH2:1][C:2]1[N:11]=[C:10]([C:12]([N:14]2[CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15]2)=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:23]3[CH:38]=[CH:37][CH:36]=[CH:35][C:24]=3[CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][CH:27]3[C:31]([OH:33])=[O:32])[CH:8]=2)[N:3]=1