Hydrochloric Acid → HCID 66836366, compound

HRID 1631163Notes

Reaction equation

HRID 1631163 reaction equation
[ClH:1].C(OC([NH:9][C@@H:10]([CH3:45])[C:11]([O:13][CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][CH:32]=1)[N:29]=[C:28]([NH2:33])[N:27]=[C:26]2[C:34]([N:36]1[CH2:44][C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37]1)=[O:35])=[O:12])=O)(C)(C)C>O1CCOCC1.ClCCl>[ClH:1].[ClH:1].[NH2:9][C@@H:10]([CH3:45])[C:11]([O:13][CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][CH:32]=1)[N:29]=[C:28]([NH2:33])[N:27]=[C:26]2[C:34]([N:36]1[CH2:44][C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37]1)=[O:35])=[O:12]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66836628HCID 66836628, compound

Product 1

HCID 66836366HCID 66836366, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
25 °C

Procedure

911 μl of 4N HCl in dioxane are added to 220 mg of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl (S)-2-tert-butoxycarbonylaminopropionate in 4 ml of dichloromethane with ice-cooling. The mixture is subsequently stirred at 25° C. for a further 1 h, the precipitate is filtered off with suction and washed with 4 ml of dichloromethane. The residue is recrystallised from ethanol.

Workup

  1. temperaturecooling
  2. filtrationthe precipitate is filtered off with suction
  3. washwashed with 4 ml of dichloromethane
  4. customThe residue is recrystallised from ethanol

Sources & evidence

ORD record
ord-fb83b5b6cabd4322baf4a23b6cd91319
Source dataset
uspto-grants-2014_07
Patent number
US08791129B2

Reaction notes

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