Hydrochloric Acid → HCID 66836626, compound

HRID 1631169Notes

Reaction equation

HRID 1631169 reaction equation
[ClH:1].C(OC([CH2:9][NH:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][C:17]1[CH:22]=[C:21]([F:23])[C:20]([F:24])=[CH:19][C:18]=1[C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)[N:31]=[C:30]([NH2:35])[N:29]=[C:28]2[C:36]([N:38]1[CH2:46][C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH2:39]1)=[O:37])=[O:14])=O)(C)(C)C>O1CCOCC1.ClCCl>[ClH:1].[ClH:1].[CH3:9][NH:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][C:17]1[CH:22]=[C:21]([F:23])[C:20]([F:24])=[CH:19][C:18]=1[C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)[N:31]=[C:30]([NH2:35])[N:29]=[C:28]2[C:36]([N:38]1[CH2:39][C:40]2[C:45](=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH2:46]1)=[O:37])=[O:14]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66836773HCID 66836773, compound

Product 1

HCID 66836626HCID 66836626, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
25 °C

Procedure

242 μl of 4N HCl in dioxane are added to 300 mg of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-(tert-butoxycarbonylmethylamino)propionate in 5 ml of dichloromethane with ice-cooling. The mixture is subsequently stirred at 25° C. for a further 1 h, the precipitate is filtered off with suction and washed with 2 ml of dichloromethane.

Workup

  1. temperaturecooling
  2. filtrationthe precipitate is filtered off with suction
  3. washwashed with 2 ml of dichloromethane

Sources & evidence

ORD record
ord-dc4cecfdd5d341f0a816581968480fc7
Source dataset
uspto-grants-2014_07
Patent number
US08791129B2

Reaction notes

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