Hydrochloric Acid → HCID 66836724, compound

HRID 1631170Notes

Reaction equation

HRID 1631170 reaction equation
[ClH:1].C(OC(CNCC[C:13]([O:15][CH2:16][C:17]1[CH:22]=[C:21]([F:23])[C:20]([F:24])=[CH:19][C:18]=1[C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)[N:31]=[C:30]([NH2:35])[N:29]=[C:28]2[C:36]([N:38]1[CH2:46][C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH2:39]1)=[O:37])=[O:14])=O)(C)(C)C>O1CCOCC1.ClCCl>[ClH:1].[ClH:1].[NH2:29][C@H:28]([CH2:36][OH:37])[C:13]([O:15][CH2:16][C:17]1[CH:22]=[C:21]([F:23])[C:20]([F:24])=[CH:19][C:18]=1[C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)[N:31]=[C:30]([NH2:35])[N:29]=[C:28]2[C:36]([N:38]1[CH2:46][C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH2:39]1)=[O:37])=[O:14]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66836773HCID 66836773, compound

Product 1

HCID 66836724HCID 66836724, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
25 °C

Procedure

1.26 ml of 4N HCl in dioxane are added to 850 mg of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-(tert-butoxycarbonylmethylamino)propionate in 20 ml of dichloromethane with ice-cooling. The mixture is subsequently stirred at 25° C. for a further 1 h, evaporated to dryness in vacuo and recrystallised from ethanol.

Workup

  1. temperaturecooling
  2. customevaporated to dryness in vacuo
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-e646f27ba22b40129a046435f1163279
Source dataset
uspto-grants-2014_07
Patent number
US08791129B2

Reaction notes

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