Hydrochloric Acid → HCID 89675018, compound

HRID 1631171Notes

Reaction equation

HRID 1631171 reaction equation
[ClH:1].C(OC([NH:9][CH2:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]=[C:27]([NH2:32])[N:26]=[C:25]2[C:33]([N:35]1[CH2:43][C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:36]1)=[O:34])=[O:12])=O)(C)(C)C>O1CCOCC1.ClCCl>[ClH:1].[ClH:1].[NH2:9][CH2:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]=[C:27]([NH2:32])[N:26]=[C:25]2[C:33]([N:35]1[CH2:36][C:37]2[C:42](=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH2:43]1)=[O:34])=[O:12]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66837694HCID 66837694, compound

Product 1

HCID 89675018HCID 89675018, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
25 °C

Procedure

5 ml of 4N HCl in dioxane are added to 1 g of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4-fluorobenzyl 2-tert-butoxycarbonylaminoacetate in 50 ml of dichloromethane with ice-cooling. The mixture is subsequently stirred at 25° C. for a further 1 h, the precipitate is filtered off and rinsed with 5 ml of dichloromethane.

Workup

  1. temperaturecooling
  2. filtrationthe precipitate is filtered off
  3. washrinsed with 5 ml of dichloromethane

Sources & evidence

ORD record
ord-2edd677a2d8f41a0b4d953f851f2811f
Source dataset
uspto-grants-2014_07
Patent number
US08791129B2

Reaction notes

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