Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 131731715 | HCID 131731715 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 89675007 | HCID 89675007 | — |
Reaction Steps
3.3 ml of 4N HCl in dioxane are added to 1 g of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl (tert-butoxycarbonylmethylamino)acetate in 20 ml of dichloromethane with ice-cooling. The mixture is subsequently stirred at 25° C. for a further 1 h, the precipitate is filtered off and rinsed with 3 ml of dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08791129B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-9602edb4c98a4df887ed5943f656e2c8 |
|---|
| Source note | uspto-grants-2014_07 |
|---|
