Hydrochloric Acid → HCID 89675007, compound

HRID 1631172Notes

Reaction equation

HRID 1631172 reaction equation
[ClH:1].C(OC([CH2:9][NH:10][CH2:11][C:12]([O:14][CH2:15][C:16]1[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=1[C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[N:30]=[C:29]([NH2:34])[N:28]=[C:27]2[C:35]([N:37]1[CH2:45][C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[CH2:38]1)=[O:36])=[O:13])=O)(C)(C)C>O1CCOCC1.ClCCl>[ClH:1].[ClH:1].[CH3:9][NH:10][CH2:11][C:12]([O:14][CH2:15][C:16]1[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=1[C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[N:30]=[C:29]([NH2:34])[N:28]=[C:27]2[C:35]([N:37]1[CH2:38][C:39]2[C:44](=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH2:45]1)=[O:36])=[O:13]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131731715HCID 131731715, compound

Product 1

HCID 89675007HCID 89675007, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
25 °C

Procedure

3.3 ml of 4N HCl in dioxane are added to 1 g of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl (tert-butoxycarbonylmethylamino)acetate in 20 ml of dichloromethane with ice-cooling. The mixture is subsequently stirred at 25° C. for a further 1 h, the precipitate is filtered off and rinsed with 3 ml of dichloromethane.

Workup

  1. temperaturecooling
  2. filtrationthe precipitate is filtered off
  3. washrinsed with 3 ml of dichloromethane

Sources & evidence

ORD record
ord-9602edb4c98a4df887ed5943f656e2c8
Source dataset
uspto-grants-2014_07
Patent number
US08791129B2

Reaction notes

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