反应详情

1.3 g of [2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate are stirred at 25° C. for 1 h in 20 ml of trifluoroacetic acid. The mixture is evaporated at 25° C. in vacuo, and the residue is taken up in 100 ml of water. The pH is adjusted to 6 using bicarbonate solution, and the precipitate formed is filtered off. Drying at 40° C. in vacuo gives product.

1. customThe mixture is evaporated at 25° C. in vacuo
2. customthe precipitate formed
3. filtrationis filtered off
4. customDrying at 40° C. in vacuo
5. customgives product