Butyric anhydride → HCID 24750071, compound

HRID 1631205Notes

Reaction equation

HRID 1631205 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:11][NH:12][C:13](=[O:15])[CH3:14])[CH:6]=[CH:7][CH:8]=1.[C:22](OC(=O)CCC)(=O)[CH2:23]CC>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:11][NH:12][C:13](=[O:15])[CH2:14][CH2:22][CH3:23])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 7798Butyric anhydrideHCID 16656789HCID 16656789, compound

Product 1

HCID 24750071HCID 24750071, compound

Procedure

The title compound was prepared according to the method previously described for the preparation of 5b, by hydrogenation of nitrile (4b) followed by N-acylation with butyric anhydride. Yield (5n): 80%; mp 50-52° C. (petroleum ether); 1H-NMR (CDCl3): δ 0.92 (t, 3H), 1.59 (m, 2H), 2.10 (t, 2H), 3.52 (m, 2H), 3.76 (s, 3H), 3.89 (t, 2H), 5.71 (brs, 1H), 6.55-6.61 (m, 3H), 7.02-7.31 (m, 6H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-945b96b7a20a42b69250c1ce4058a166
Source dataset
uspto-grants-2014_07
Patent number
US08791163B2

Reaction notes

Loading…