Triphenylphosphine → HCID 178453006, compound

HRID 1631228Notes

Reaction equation

HRID 1631228 reaction equation
[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[NH:12][C:11]([CH2:13]O)=[N:10][N:9]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:18]=1[SH:24].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CC(OC(/N=N/C(OC(C)(C)C)=O)=O)(C)C>C(Cl)Cl>[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[NH:12][C:11]([CH2:13][S:24][C:18]2[CH:19]=[CH:20][C:21]([Cl:23])=[CH:22][C:17]=2[NH2:16])=[N:10][N:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 11776TriphenylphosphineHCID 120002-Amino-4-chlorobenzenethiolHCID 6034084Di-tert-butyl diazene-1,2-dicarboxylateHCID 178453005HCID 178453005, compound

Product 1

HCID 178453006HCID 178453006, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl(5-(hydroxymethyl)-4H-1,2,4-triazol-3-yl)carbamate (190 mg, 0.888 mmol), 2-amino-4-chlorobenzenethiol (213 mg, 1.332 mmol), PPh3 (466 mg, 1.776 mmol) and di-tert-butylazodicarboxylate (409 mg, 1.776 mmol) in CH2Cl2 (10 ml) was stirred at room temperature for 2 days. The solvent was then removed and the crude residues was loaded on silica gel column to get the title compound.

Workup

  1. customThe solvent was then removed

Sources & evidence

ORD record
ord-96231064558046c9bc27e1b8a6e4f4d4
Source dataset
uspto-grants-2014_07
Patent number
US08791161B2

Reaction notes

Loading…