Tert-Butylamine → HCID 66851763, compound

HRID 1631326Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][C@@H:11]([OH:13])[CH2:10][N:9]2[C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23]([OH:25])=O)=[C:16]3[N:15]=2)[CH:5]=[CH:6][CH:7]=1.[C:26]([NH2:30])([CH3:29])([CH3:28])[CH3:27]>>[C:26]([NH:30][C:23]([C:22]1[CH:21]=[N:20][N:17]2[CH:18]=[CH:19][C:14]([N:9]3[CH2:10][C@H:11]([OH:13])[CH2:12][C@@H:8]3[C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)=[N:15][C:16]=12)=[O:25])([CH3:29])([CH3:28])[CH3:27]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 66847779HCID 66847779, compound

Product 1

HCID 66851763HCID 66851763, compoundYield 100%

Procedure

Prepared by the method described in Example 1 using 5-((2R,4R)-2-(3-fluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid and tert-butyl amine to provide the final product as a white solid (24 mg, 100% yield). MS (apci) m/z=398.1 (M+H).

Workup

customPrepared by the method

Sources & evidence

ORD record: ord-f78caeb6ac20499b8fcd9c396bd04c5a
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08791123B2

Reaction notes

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